Associate Director, Biostatistics
Boston Full-time Director Data Science
At a glance
Director-level Data Science role at Rhythm Pharmaceuticals. Boston · full-time · $160,000–$240,000 base.
SalaryStated by Rhythm Pharmaceuticals
$160,000 – $240,000
Base salary for this role, in USD per year, as published in the posting.
This role, from Rhythm PharmaceuticalsOur estimate for the market: $214,513–$255,000Median $235,981
The range includes the market median of $235,981 for lead data science roles in Boston.
Worked out from 12 postings that stated pay, median $235,981. Last updated Oct 23, 2026.
RoleData Science
SeniorityDirector
LocationBoston
EmploymentFull-time
Base pay$160,000–$240,000
PostedAug 21, 2026 · 2mo ago
Role brief
dataroles summary, based on the employer's posting.
What you'll do
- Lead statistics for assigned clinical studies, shaping study plans, power calculations, protocols, analysis plans and results interpretation
- Work with clinical, regulatory, safety, data management and programming teams to bring statistical input into study decisions
- Draft or review statistical material for study reports, safety and efficacy summaries, and regulatory documents
- Check vendor and programming outputs, including dry runs, to catch analysis or data issues and resolve them promptly
- Support interim analyses, DSMB meetings, regulatory submissions, and improvements to statistical standards and processes
What you bring
- A PhD with about five or more years of relevant clinical trial work, or a master’s degree with about eight or more years
- Proficiency in SAS and R, plus familiarity with CDISC standards such as SDTM and ADaM
- Working knowledge of clinical trial methods and drug development, with experience supporting studies in at least one development phase
- Strong communication and writing skills, and the ability to manage competing timelines without sacrificing accuracy
Who this fits
This hands-on statistical lead role suits someone who can work independently while partnering across functions and adjusting as priorities shift. You’ll need to work from the Boston office in coordination with department and business needs under a hybrid model. Some travel may be involved.
From the employer
Company Overview
Rhythm is a global, commercial-stage biopharmaceutical company committed to transforming the lives of patients living with rare neuroendocrine diseases. We develop medicines for previously untreatable or undertreated diseases. We recognize the courage it takes for patients and their caregivers to begin their journey of advocacy to find the answers they need. Their courage inspires us to challenge convention, ask bold questions and seek answers for them. Every day, we strive for excellence through our willingness to adapt, learn, and our tenacity to overcome barriers, together.
Opportunity Overview
Rhythm is seeking an Associate Director, Biostatistics to join our Biostatistics team and support important clinical development programs. Reporting to the Vice President, Head of Biostatistics & Statistical Programming, this individual will serve as a hands-on statistical lead for assigned studies or program activities, partnering across clinical, regulatory, safety, data management, and programming teams to support robust study design, high-quality analyses, and clear interpretation of results. The ideal candidate is an independent, collaborative, and solutions-oriented biostatistician who brings strong technical judgment, attention to quality, and the ability to contribute effectively in a dynamic, nimble biotech environment where priorities may evolve quickly.
Responsibilities and Duties
Qualifications and Skills
This role is based out of our corporate office in Boston, Massachusetts. Rhythm operates in a hybrid-work model. Candidates applying must be willing and able to be in the Boston office in coordination with their department and business needs. This role may involve some travel.
The expected salary range for this position is $160,000 - $240,000. Actual pay will be determined based on experience, level, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and company performance. This role may be eligible for benefits and other compensation such as restricted stock units.
More about Rhythm
We are a dynamic and growing global team spanning more than a dozen countries. At Rhythm we are dedicated to transforming the lives of patients living with rare neuroendocrine diseases by rapidly advancing care and precision medicines that address the root cause. Our team is passionate about expanding access to reach more patients and developing novel therapies for other rare neuroendocrine diseases, including congenital hyperinsulinism.
At Rhythm our core values are:
Inherent in our core values is the commitment to act ethically and with integrity in all we do.
Rhythm is an equal employment opportunity employer and does not discriminate against any applicant because of race, creed, color, age, national origin, ancestry, religion, gender, sexual orientation, disability, genetic information, veteran status, military status, application for military service, or any other class protected by state or federal law.
Headquartered in Boston, Rhythm is proud to have been named one of the Top Places to Work in Massachusetts.
Rhythm is a global, commercial-stage biopharmaceutical company committed to transforming the lives of patients living with rare neuroendocrine diseases. We develop medicines for previously untreatable or undertreated diseases. We recognize the courage it takes for patients and their caregivers to begin their journey of advocacy to find the answers they need. Their courage inspires us to challenge convention, ask bold questions and seek answers for them. Every day, we strive for excellence through our willingness to adapt, learn, and our tenacity to overcome barriers, together.
Opportunity Overview
Rhythm is seeking an Associate Director, Biostatistics to join our Biostatistics team and support important clinical development programs. Reporting to the Vice President, Head of Biostatistics & Statistical Programming, this individual will serve as a hands-on statistical lead for assigned studies or program activities, partnering across clinical, regulatory, safety, data management, and programming teams to support robust study design, high-quality analyses, and clear interpretation of results. The ideal candidate is an independent, collaborative, and solutions-oriented biostatistician who brings strong technical judgment, attention to quality, and the ability to contribute effectively in a dynamic, nimble biotech environment where priorities may evolve quickly.
Responsibilities and Duties
- Serve as the statistical lead for assigned clinical studies or defined program activities, contributing to clinical development plans, study design, sample size and power calculations, protocols, statistical analysis plans (SAPs), TLFs, data analyses, and interpretation of results.
- Collaborate with cross-functional partners to support study strategy, execution, and decision-making, ensuring statistical considerations are clearly incorporated into clinical plans and deliverables.
- Prepare and review statistical content for protocols, clinical study reports, integrated summaries of safety and efficacy, and other submission-related or study-level documents.
- Oversee statistical vendors for assigned deliverables, including review, validation, and quality control of outputs to ensure accuracy, consistency, and compliance with Rhythm standards.
- Work closely with statistical programmers to review key efficacy and safety outputs, support dry runs and quality control, identify data or analysis issues, and help drive timely resolution.
- Support interim analyses, DSMB meetings, ad hoc analyses, and other statistical activities required to advance clinical program needs.
- Contribute to statistical components of global regulatory submissions, including relevant sections of CTD Modules 2.5, 2.7, and 5, as needed.
- Support the presentation of statistical analyses and results in INDs, NDAs, BLAs, MAAs, J-NDAs, and other regulatory submissions or briefing materials.
- Partner with data management on CRFs, data management plans, edit checks, data review activities, and related processes that support high-quality analysis outputs.
- Contribute to departmental standards, templates, process improvements, and practical solutions that enhance quality, efficiency, and inspection readiness.
Qualifications and Skills
- PhD in Statistics, Biostatistics, or a related quantitative discipline preferred, with approximately 5+ years of relevant clinical trial experience in biopharma, biotech, or CRO settings; or MS in Statistics, Biostatistics, or a related discipline with approximately 8+ years of relevant experience.
- Strong understanding of statistical concepts and clinical trial methodologies, with the ability to apply them thoughtfully to practical development and analysis challenges.
- Knowledge of the drug development process and experience supporting clinical studies across one or more phases of development.
- Proficiency with SAS and R; experience with sample size software such as EAST preferred.
- Familiarity with CDISC requirements, including SDTM and ADaM standards.
- Experience contributing to IND, NDA, BLA, MAA, J-NDA, or other regulatory submission deliverables is preferred but not required.
- Ability to manage multiple priorities, projects, and timelines while maintaining strong attention to quality and detail.
- Excellent communication, presentation, and report-writing skills, with the ability to explain complex statistical concepts clearly to cross-functional and non-statistical audiences.
- Ability to work independently within established strategic direction, collaborate effectively across functions, and adapt to evolving priorities in a fast-paced biotech environment.
This role is based out of our corporate office in Boston, Massachusetts. Rhythm operates in a hybrid-work model. Candidates applying must be willing and able to be in the Boston office in coordination with their department and business needs. This role may involve some travel.
The expected salary range for this position is $160,000 - $240,000. Actual pay will be determined based on experience, level, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and company performance. This role may be eligible for benefits and other compensation such as restricted stock units.
More about Rhythm
We are a dynamic and growing global team spanning more than a dozen countries. At Rhythm we are dedicated to transforming the lives of patients living with rare neuroendocrine diseases by rapidly advancing care and precision medicines that address the root cause. Our team is passionate about expanding access to reach more patients and developing novel therapies for other rare neuroendocrine diseases, including congenital hyperinsulinism.
At Rhythm our core values are:
- We are committed to advancing scientific understanding to improve patients’ lives
- We are inspired to tackle tough challenges and have the courage to ask bold questions
- We are eager to learn and adapt
- We believe collaboration and ownership are foundational for our success
- We value the unique contribution each individual brings to furthering our mission
Inherent in our core values is the commitment to act ethically and with integrity in all we do.
Rhythm is an equal employment opportunity employer and does not discriminate against any applicant because of race, creed, color, age, national origin, ancestry, religion, gender, sexual orientation, disability, genetic information, veteran status, military status, application for military service, or any other class protected by state or federal law.
Headquartered in Boston, Rhythm is proud to have been named one of the Top Places to Work in Massachusetts.
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