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Senior Biostatistician II

Vertex Pharmaceuticals Open · verified Oct 24, 2026
Boston Full-time Senior Data Science

At a glance

Senior Data Science role at Vertex Pharmaceuticals. Boston · full-time · $132,200–$198,200 base.

SalaryStated by Vertex Pharmaceuticals
$132,200 – $198,200
Base salary for this role, in USD per year, as published in the posting.
This role, from Vertex PharmaceuticalsOur estimate for the market: $143,863–$204,563Median $163,850
The range includes the market median of $163,850 for senior data science roles in Boston.
Worked out from 20 postings that stated pay, median $163,850. Last updated Oct 23, 2026.
RoleData Science
SenioritySenior
LocationBoston
EmploymentFull-time
Base pay$132,200–$198,200
PostedSep 24, 2026 · 4w ago
Role brief

dataroles summary, based on the employer's posting.

What you'll do

  • Set up statistical methods and infrastructure for clinical trials, observational research, and real-world data studies
  • Prepare study analysis plans with table, figure, and listing outlines, then take them to statistical review
  • Lead reviews of study data and key results, and plan how findings will be shared
  • Coordinate with statistical programmers and other functions to deliver accurate tables, figures, and listings on time
  • Write protocol statistics, including sample-size calculations and randomization plans, and contribute to clinical study reports

What you bring

  • A PhD or master's degree in statistics or biostatistics
  • With a master's degree, typically three years of experience or an equivalent mix of education and work
  • Proficiency with SAS and R, and familiarity with statistical approaches applied in drug development

Who this fits

This role suits a senior statistician who can collaborate with programmers and non-statistical colleagues while developing study methods with supervision and support on complex questions. The Boston position offers a hybrid option with remote work up to two days each week, or an on-site option for five days weekly.

From the employer

Job Description

General Summary:

The Senior Biostatistician II will perform scientific statistical analyses in support of the company's Global Medicines Development and Affairs area with guidance and mentoring on new and complex issues. The incumbent will complete assigned work in a resourceful manner and create alternative approaches to achieve desired results. The incumbent will develop a good knowledge of related disciplines while performing Biostatistics activities with a drug developer mindset.

Key Duties and Responsibilities:

  • Within assigned area, designs, develops and executes the technical/statistical infrastructure for the conduct and evaluation of clinical trials, observational studies, or real world data (RWD) investigations, including related areas/activities.
  • Participates in regular Study Execution Team (SET) team meetings as the functional representative.
  • Works under supervision to author study Statistical Analysis Plans (SAPs), including table, figure, and listing (TFL) shells, and presentation to Statistical Review Forum (SRF).
  • Plans and conducts Cross-functional Data Review (xFDR) , Key Results Memo (KRM), and Data Dissemination Plan (DDP) in order to facilitate the review, summary, and dissemination of key study data/results.
  • Collaborates with statistical programming and other functions to ensure timely delivery of TFLs with good quality. Provides input into programming specifications and review.
  • Develops statistical section of protocols, including sample size estimates and randomization plan.
  • Contributes to clinical study reports (CSRs) and related processes. May author or co-author methodological or study-related publications and posters.
  • Implements design and analysis methods at the study level and participates in SRF discussions of studies assigned to others.
  • Contributes to departmental working group efforts on various technical and operational issues.
  • Seeks guidance and mentoring on new and complex issues
  • Completes assigned work in a resourceful manner and creates alternative approaches to achieve desired results if needed.
  • Develops a basic knowledge of related disciplines with a drug developer mindset.
  • Knowledge and Skills:

  • Competence with SAS and R statistical software
  • Demonstrated understanding of statistical methods used in drug development
  • Ability to show critical thinking with logical problem-solving
  • Excellent written and verbal communication skills
  • Excels in a team environment
  • Collaborates well with non-statisticians
  • Education and Experience:

  • Ph. D. or master's degree in Statistics or Biostatistics.
  • Typically requires 3 years of experience for those with a master's degree or the equivalent combination of education and experience.

  • At Vertex, we embrace continuous learning and encourage employees to stay informed on advances in AI, technology, automation, and industry trends. We seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities that improve decision-making, drive innovation, increase efficiency, and help deliver better outcomes for patients.

    Pay Range:

    $132,200 - $198,200

    Disclosure Statement:

    The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.

    At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.

    Flex Designation:

    Hybrid-Eligible Or On-Site Eligible

    Flex Eligibility Status:

    In this Hybrid-Eligible role, you can choose to be designated as:
    1. Hybrid: work remotely up to two days per week; or select
    2. On-Site: work five days per week on-site with ad hoc flexibility.

    Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time.


    Company Information

    Vertex is a global biotechnology company that invests in scientific innovation.

    Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

    Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com

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    Data Science work from LinkedIn, X, Reddit and Upwork, in one list.

    Each morning you get everything that fits, strongest first.

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    By the team behind dataroles.