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Principal Biostatistician

Vertex Pharmaceuticals Open · verified Oct 24, 2026
Boston Full-time Senior Data Science

At a glance

Senior Data Science role at Vertex Pharmaceuticals. Boston · full-time · $152,000–$228,000 base.

SalaryStated by Vertex Pharmaceuticals
$152,000 – $228,000
Base salary for this role, in USD per year, as published in the posting.
This role, from Vertex PharmaceuticalsOur estimate for the market: $143,863–$204,563Median $163,850
The range includes the market median of $163,850 for senior data science roles in Boston.
Worked out from 20 postings that stated pay, median $163,850. Last updated Oct 23, 2026.
RoleData Science
SenioritySenior
LocationBoston
EmploymentFull-time
Base pay$152,000–$228,000
PostedSep 8, 2026 · 6w ago
Role brief

dataroles summary, based on the employer's posting.

What you'll do

  • Design and run statistical work across clinical trials, observational studies and real-world data investigations
  • Write study analysis plans and their table, figure and listing shells, with little supervision
  • Set up data-review and dissemination plans so teams can assess and share study results
  • Develop protocol statistics, including sample-size calculations and randomization plans
  • Work with programmers on timely, high-quality outputs and contribute to study reports and publications

What you bring

  • A Ph.D. in statistics or biostatistics, or a master's degree with the required experience
  • Typically, three years of experience after a Ph.D. or six after a master's, or an equivalent mix
  • Strong working knowledge of SAS and R, plus advanced statistical methods used in drug development

Who this fits

This senior role suits a statistician who can handle complex study work independently while collaborating with clinical teams, programmers and non-statisticians. The position is based in Boston and offers a choice of remote work up to two days weekly or working on-site five days weekly. The stated base salary range is $152,000 to $228,000 per year.

From the employer

Job Description

General Summary:

The Principal Biostatistician will perform advanced scientific statistical analyses in support of the company's Global Medicines Development and Affairs area with some guidance and mentoring on new and complex issues. The incumbent will completed work in a resourceful, self-sufficient manner and create alternative approaches to achieve desired results. The incumbent should possess a good knowledge of related disciplines while performing Biostatistics activities with a drug developer mindset.

Key Duties and Responsibilities:

  • Conducts advanced scientific and operational statistical work for multiple clinical trials, observational studies, or real world data (RWD) investigations, including the design, development and execution of the technical/statistical infrastructure.
  • Possesses an advanced understanding of modern drug discovery and development processes.
  • Represents Biostatistics as a member of clinical trial teams, providing input and technical guidance to elicit meaningful and/or productive outcomes.
  • With minimal guidance, authors study Statistical Analysis Plans (SAPs), including table, figure, and listing (TFL) shells. Develops Cross-functional Data Review (xFDR) plan, Key Reports Memo (KRM), and Data Dissemination Plan (DDP) to facilitate the review, summary, and dissemination of key study data/results.
  • Collaborates with statistical programming and other functions to ensure timely delivery of TFLs with good quality.
  • Contributes to external interactions with regulators, payers, review boards, etc.
  • Develops statistical section of protocols, including sample size estimates and randomization plans.
  • Contributes to clinical study reports (CSRs) and related processes. Also authors or co-authors methodological or study-related publications and posters. Provides input into programming specifications and review.
  • Implements design and analysis methods at the study level and participates in Statistical Review Forum (SRF) discussions of studies assigned to others.
  • Contributes to departmental working group efforts on various advanced technical and operational issues.
  • Undertakes new and complex issues with minimal guidance
  • Completes assigned work in a resourceful, self-sufficient manner and creates alternative approaches to achieve desired results if needed.
  • Develops breadth of knowledge across related disciplines with a drug developer mindset.
  • Knowledge and Skills:

  • In-depth experience with SAS and R statistical software
  • Demonstrated understanding of advanced statistical methods used in drug development
  • Ability to show critical thinking with logical problem-solving
  • Excellent written and verbal communication skills
  • Excels in a team environment
  • Collaborates well with non-statisticians
  • Education and Experience:

  • Ph. D. or master's degree in Statistics or Biostatistics.
  • Typically requires 3 years of experience with a Ph.D. or 6 years of experience with a master's degree, or the equivalent combination of education and experience.

  • At Vertex, we embrace continuous learning and encourage employees to stay informed on advances in AI, technology, automation, and industry trends. We seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities that improve decision-making, drive innovation, increase efficiency, and help deliver better outcomes for patients.

    Pay Range:

    $152,000 - $228,000

    Disclosure Statement:

    The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.

    At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.

    Flex Designation:

    Hybrid-Eligible Or On-Site Eligible

    Flex Eligibility Status:

    In this Hybrid-Eligible role, you can choose to be designated as:
    1. Hybrid: work remotely up to two days per week; or select
    2. On-Site: work five days per week on-site with ad hoc flexibility.

    Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time.


    Company Information

    Vertex is a global biotechnology company that invests in scientific innovation.

    Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

    Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com

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    Each morning you get everything that fits, strongest first.

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